SIRT1 stabilizes extrachromosomal gene amplification and contributes to repeat-induced gene silencing

Sirtuin 1 (SIRT1) is a protein deacetylase that maintains genome stability by preventing the activation of latent replication origins. Amplified genes in cancer cells localize on either extrachromosomal double minutes (DMs) or the chromosomal homogeneously staining region. Previously, we found that...

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Detalles Bibliográficos
Autores principales: Taniguchi, Ryonosuke, Utani, Koichi, Thakur, Bhushan, Ishine, Kazuho, Aladjem, Mirit I., Shimizu, Noriaki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7949162/
https://www.ncbi.nlm.nih.gov/pubmed/33539925
http://dx.doi.org/10.1016/j.jbc.2021.100356

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7949162/
https://www.ncbi.nlm.nih.gov/pubmed/33539925
http://dx.doi.org/10.1016/j.jbc.2021.100356

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