Thermal Proteome Profiling in Zebrafish Reveals Effects of Napabucasin on Retinoic Acid Metabolism

Thermal proteome profiling (TPP) allows for the unbiased detection of drug–target protein engagements in vivo. Traditionally, 1 cell type is used for TPP studies, with the risk of missing important differentially expressed target proteins. The use of whole organisms would circumvent this problem. Ze...

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Detalles Bibliográficos
Autores principales: Leijten, Niels M., Bakker, Petra, Spaink, Herman P., den Hertog, Jeroen, Lemeer, Simone
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2021
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7950114/
https://www.ncbi.nlm.nih.gov/pubmed/33594990
http://dx.doi.org/10.1074/mcp.RA120.002273

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7950114/
https://www.ncbi.nlm.nih.gov/pubmed/33594990
http://dx.doi.org/10.1074/mcp.RA120.002273

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