Cholesterol activates BK channels by increasing KCNMB1 protein levels in the plasmalemma

Calcium-/voltage-gated, large-conductance potassium channels (BKs) control critical physiological processes, including smooth muscle contraction. Numerous observations concur that elevated membrane cholesterol (CLR) inhibits the activity of homomeric BKs consisting of channel-forming alpha subunits....

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Detalles Bibliográficos
Autores principales: Bukiya, Anna N., Leo, M. Dennis, Jaggar, Jonathan H., Dopico, Alex M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7950327/
https://www.ncbi.nlm.nih.gov/pubmed/33556372
http://dx.doi.org/10.1016/j.jbc.2021.100381

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7950327/
https://www.ncbi.nlm.nih.gov/pubmed/33556372
http://dx.doi.org/10.1016/j.jbc.2021.100381

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