Direct interaction of HIV gp120 with neuronal CXCR4 and CCR5 receptors induces cofilin-actin rod pathology via a cellular prion protein- and NOX-dependent mechanism

Nearly 50% of individuals with long-term HIV infection are affected by the onset of progressive HIV-associated neurocognitive disorders (HAND). HIV infiltrates the central nervous system (CNS) early during primary infection where it establishes persistent infection in microglia (resident macrophages...

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Detalles Bibliográficos
Autores principales: Smith, Lisa K., Babcock, Isaac W., Minamide, Laurie S., Shaw, Alisa E., Bamburg, James R., Kuhn, Thomas B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7951892/
https://www.ncbi.nlm.nih.gov/pubmed/33705493
http://dx.doi.org/10.1371/journal.pone.0248309

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7951892/
https://www.ncbi.nlm.nih.gov/pubmed/33705493
http://dx.doi.org/10.1371/journal.pone.0248309

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