Converting melanoma-associated fibroblasts into a tumor-suppressive phenotype by increasing intracellular Notch1 pathway activity

Cancer-associated fibroblasts (CAFs) play a crucial role in cancer progression, drug resistance and tumor recurrence. We have recently shown that the Notch pathway determines the tumor-regulatory role of experimentally created ‘CAFs’. Here, we examined the status of Notch signaling in human melanoma...

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Detalles Bibliográficos
Autores principales: Shao, Hongwei, Moller, Mecker, Cai, Long, Prokupets, Rochelle, Yang, Cuixia, Costa, Connor, Yu, Kerstin, Le, Nga, Liu, Zhao-Jun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7951899/
https://www.ncbi.nlm.nih.gov/pubmed/33705467
http://dx.doi.org/10.1371/journal.pone.0248260

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7951899/
https://www.ncbi.nlm.nih.gov/pubmed/33705467
http://dx.doi.org/10.1371/journal.pone.0248260

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