Circular ANRIL isoforms switch from repressors to activators of p15/CDKN2B expression during RAF1 oncogene-induced senescence

Long non-coding RNAs (ncRNAs) are major regulators of gene expression and cell fate. The INK4 locus encodes the tumour suppressor proteins p15(INK4b), p16(INK4a) and p14(ARF) required for cell cycle arrest and whose expression increases during senescence. ANRIL is a ncRNA antisense to the p15 gene....

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Detalles Bibliográficos
Autores principales: Muniz, Lisa, Lazorthes, Sandra, Delmas, Maxime, Ouvrard, Julien, Aguirrebengoa, Marion, Trouche, Didier, Nicolas, Estelle
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2020
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7951966/
https://www.ncbi.nlm.nih.gov/pubmed/32862732
http://dx.doi.org/10.1080/15476286.2020.1812910

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7951966/
https://www.ncbi.nlm.nih.gov/pubmed/32862732
http://dx.doi.org/10.1080/15476286.2020.1812910

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