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Circular ANRIL isoforms switch from repressors to activators of p15/CDKN2B expression during RAF1 oncogene-induced senescence
Long non-coding RNAs (ncRNAs) are major regulators of gene expression and cell fate. The INK4 locus encodes the tumour suppressor proteins p15(INK4b), p16(INK4a) and p14(ARF) required for cell cycle arrest and whose expression increases during senescence. ANRIL is a ncRNA antisense to the p15 gene....
| Autores principales: | , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Taylor & Francis
2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7951966/ https://www.ncbi.nlm.nih.gov/pubmed/32862732 http://dx.doi.org/10.1080/15476286.2020.1812910 |