Glycoprotein N-linked glycans play a critical role in arenavirus pathogenicity

Several arenaviruses cause hemorrhagic fevers in humans with high case fatality rates. A vaccine named Candid#1 is available only against Junin virus (JUNV) in Argentina. Specific N-linked glycans on the arenavirus surface glycoprotein (GP) mask important epitopes and help the virus evade antibody r...

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Detalles Bibliográficos
Autores principales: Koma, Takaaki, Huang, Cheng, Coscia, Adrian, Hallam, Steven, Manning, John T., Maruyama, Junki, Walker, Aida G., Miller, Milagros, Smith, Jeanon N., Patterson, Michael, Abraham, Jonathan, Paessler, Slobodan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7951981/
https://www.ncbi.nlm.nih.gov/pubmed/33647064
http://dx.doi.org/10.1371/journal.ppat.1009356

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7951981/
https://www.ncbi.nlm.nih.gov/pubmed/33647064
http://dx.doi.org/10.1371/journal.ppat.1009356

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