Reformulation of an extant ATPase active site to mimic ancestral GTPase activity reveals a nucleotide base requirement for function

Hydrolysis of nucleoside triphosphates releases similar amounts of energy. However, ATP hydrolysis is typically used for energy-intensive reactions, whereas GTP hydrolysis typically functions as a switch. SpoIVA is a bacterial cytoskeletal protein that hydrolyzes ATP to polymerize irreversibly durin...

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Detalles Bibliográficos
Autores principales: Updegrove, Taylor B, Harke, Jailynn, Anantharaman, Vivek, Yang, Jin, Gopalan, Nikhil, Wu, Di, Piszczek, Grzegorz, Stevenson, David M, Amador-Noguez, Daniel, Wang, Jue D, Aravind, L, Ramamurthi, Kumaran S
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2021
Materias:
Cell Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7952092/
https://www.ncbi.nlm.nih.gov/pubmed/33704064
http://dx.doi.org/10.7554/eLife.65845

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7952092/
https://www.ncbi.nlm.nih.gov/pubmed/33704064
http://dx.doi.org/10.7554/eLife.65845

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