Polymerase-guided base editing enables in vivo mutagenesis and rapid protein engineering

Random mutagenesis is a technique used to generate diversity and engineer biological systems. In vivo random mutagenesis generates diversity directly in a host organism, enabling applications such as lineage tracing, continuous evolution, and protein engineering. Here we describe TRIDENT (TaRgeted I...

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Detalles Bibliográficos
Autores principales: Cravens, Aaron, Jamil, Osman K., Kong, Deze, Sockolosky, Jonathan T., Smolke, Christina D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7952560/
https://www.ncbi.nlm.nih.gov/pubmed/33707425
http://dx.doi.org/10.1038/s41467-021-21876-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7952560/
https://www.ncbi.nlm.nih.gov/pubmed/33707425
http://dx.doi.org/10.1038/s41467-021-21876-z

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