Overcoming the design, build, test bottleneck for synthesis of nonrepetitive protein-RNA cassettes

We apply an oligo-library and machine learning-approach to characterize the sequence and structural determinants of binding of the phage coat proteins (CPs) of bacteriophages MS2 (MCP), PP7 (PCP), and Qβ (QCP) to RNA. Using the oligo library, we generate thousands of candidate binding sites for each...

Descripción completa

Detalles Bibliográficos
Autores principales: Katz, Noa, Tripto, Eitamar, Granik, Naor, Goldberg, Sarah, Atar, Orna, Yakhini, Zohar, Orenstein, Yaron, Amit, Roee
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7952577/
https://www.ncbi.nlm.nih.gov/pubmed/33707432
http://dx.doi.org/10.1038/s41467-021-21578-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7952577/
https://www.ncbi.nlm.nih.gov/pubmed/33707432
http://dx.doi.org/10.1038/s41467-021-21578-6

Ejemplares similares