An extended APOBEC3A mutation signature in cancer

APOBEC mutagenesis, a major driver of cancer evolution, is known for targeting TpC sites in DNA. Recently, we showed that APOBEC3A (A3A) targets DNA hairpin loops. Here, we show that DNA secondary structure is in fact an orthogonal influence on A3A substrate optimality and, surprisingly, can overrid...

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Detalles Bibliográficos
Autores principales: Langenbucher, Adam, Bowen, Danae, Sakhtemani, Ramin, Bournique, Elodie, Wise, Jillian F., Zou, Lee, Bhagwat, Ashok S., Buisson, Rémi, Lawrence, Michael S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7952602/
https://www.ncbi.nlm.nih.gov/pubmed/33707442
http://dx.doi.org/10.1038/s41467-021-21891-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7952602/
https://www.ncbi.nlm.nih.gov/pubmed/33707442
http://dx.doi.org/10.1038/s41467-021-21891-0

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