A crucial role for Jagunal homolog 1 in humoral immunity and antibody glycosylation in mice and humans

Jagunal homolog 1 (JAGN1) has been identified as a critical regulator of neutrophil biology in mutant mice and rare-disease patients carrying JAGN1 mutations. Here, we report that Jagn1 deficiency results in alterations in the endoplasmic reticulum (ER) of antibody-producing cells as well as decreas...

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Detalles Bibliográficos
Autores principales: Hagelkruys, Astrid, Wirnsberger, Gerald, Stadlmann, Johannes, Wöhner, Miriam, Horrer, Marion, Vilagos, Bojan, Jonsson, Gustav, Kogler, Melanie, Tortola, Luigi, Novatchkova, Maria, Bönelt, Peter, Hoffmann, David, Koglgruber, Rubina, Steffen, Ulrike, Schett, Georg, Busslinger, Meinrad, Bergthaler, Andreas, Klein, Christoph, Penninger, Josef M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7953624/
https://www.ncbi.nlm.nih.gov/pubmed/32930709
http://dx.doi.org/10.1084/jem.20200559

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7953624/
https://www.ncbi.nlm.nih.gov/pubmed/32930709
http://dx.doi.org/10.1084/jem.20200559

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