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Bupivacaine inhibits a small conductance calcium‐activated potassium type 2 channel in human embryonic kidney 293 cells

BACKGROUND: Bupivacaine blocks many ion channels in the heart muscle, causing severe cardiotoxicity. Small-conductance calcium-activated potassium type 2 channels (SK2 channels) are widely distributed in the heart cells and are involved in relevant physiological functions. However, whether bupivacai...

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Detalles Bibliográficos
Autores principales: Chen, Hongfei, Jin, Zhousheng, Xia, Fangfang, Fu, Zhijian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7953788/
https://www.ncbi.nlm.nih.gov/pubmed/33712065
http://dx.doi.org/10.1186/s40360-021-00481-2