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P4HA1 Down-Regulation Inhibits Glioma Invasiveness by Promoting M1 Microglia Polarization

BACKGROUND: Polarization of microglia cells in the glioma microenvironment is closely related to the malignant progression and invasion of gliomas. Prolyl 4-hydroxylase subunit α1 (P4HA1) is the rate-limiting subunit of prolyl 4-hydroxylase (P4H). In previous studies, we showed that P4HA1 could prom...

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Detalles Bibliográficos
Autores principales: Wang, Qiyan, Zhang, Junwen, Fang, Sheng, Wang, Jialin, Han, Xiangming, Liu, Fusheng, Jin, Guishan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7954035/
https://www.ncbi.nlm.nih.gov/pubmed/33727827
http://dx.doi.org/10.2147/OTT.S299977