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CLP290 promotes the sedative effects of midazolam in neonatal rats in a KCC2-dependent manner: A laboratory study in rats

Immature neurons dominantly express the Na(+)-K(+)-2Cl(-) cotransporter isoform 1 (NKCC1) rather than the K(+)-Cl(-) cotransporter isoform 2 (KCC2). The intracellular chloride ion concentration ([Cl(-)]i) is higher in immature neurons than in mature neurons; therefore, γ-aminobutyric acid type A (GA...

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Detalles Bibliográficos
Autores principales: Doi, Akiko, Miyazaki, Tomoyuki, Mihara, Takahiro, Ikeda, Maiko, Niikura, Ryo, Andoh, Tomio, Goto, Takahisa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7954344/
https://www.ncbi.nlm.nih.gov/pubmed/33711029
http://dx.doi.org/10.1371/journal.pone.0248113