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CLP290 promotes the sedative effects of midazolam in neonatal rats in a KCC2-dependent manner: A laboratory study in rats
Immature neurons dominantly express the Na(+)-K(+)-2Cl(-) cotransporter isoform 1 (NKCC1) rather than the K(+)-Cl(-) cotransporter isoform 2 (KCC2). The intracellular chloride ion concentration ([Cl(-)]i) is higher in immature neurons than in mature neurons; therefore, γ-aminobutyric acid type A (GA...
| Autores principales: | , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2021
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7954344/ https://www.ncbi.nlm.nih.gov/pubmed/33711029 http://dx.doi.org/10.1371/journal.pone.0248113 |