Extended plasma half-life of albumin-binding domain fused human IgA upon pH-dependent albumin engagement of human FcRn in vitro and in vivo

Albumin has a serum half-life of 3 weeks in humans. This feature can be used to improve the pharmacokinetics of shorter-lived biologics. For instance, an albumin-binding domain (ABD) can be used to recruit albumin. A prerequisite for such design is that the ABD-albumin interaction does not interfere...

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Detalles Bibliográficos
Autores principales: Mester, Simone, Evers, Mitchell, Meyer, Saskia, Nilsen, Jeannette, Greiff, Victor, Sandlie, Inger, Leusen, Jeanette, Andersen, Jan Terje
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2021
Materias:
Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7954421/
https://www.ncbi.nlm.nih.gov/pubmed/33691596
http://dx.doi.org/10.1080/19420862.2021.1893888

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7954421/
https://www.ncbi.nlm.nih.gov/pubmed/33691596
http://dx.doi.org/10.1080/19420862.2021.1893888

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