CNS Autoimmune Responses in BCMA-Deficient Mice Provide Insight for the Failure of Atacicept in MS

OBJECTIVE: B cells have emerged as a therapeutic target for MS. Anti-CD20 antibodies, which deplete B cells, are effective therapies for MS. However, atacicept (TACI-Fc), which blocks BAFF and APRIL and reduces B cells, unexpectedly exacerbates MS. We tested the hypothesis that B cell maturation ant...

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Detalles Bibliográficos
Autores principales: Kumar, Gaurav, Maria, Zahra, Kohli, Uday, Agasing, Agnieshka, Quinn, James L., Ko, Rose M., Zamvil, Scott S., Axtell, Robert C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7954465/
https://www.ncbi.nlm.nih.gov/pubmed/33649164
http://dx.doi.org/10.1212/NXI.0000000000000973

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7954465/
https://www.ncbi.nlm.nih.gov/pubmed/33649164
http://dx.doi.org/10.1212/NXI.0000000000000973

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