DDK regulates replication initiation by controlling the multiplicity of Cdc45-GINS binding to Mcm2-7

The committed step of eukaryotic DNA replication occurs when the pairs of Mcm2-7 replicative helicases that license each replication origin are activated. Helicase activation requires the recruitment of Cdc45 and GINS to Mcm2-7, forming Cdc45-Mcm2-7-GINS complexes (CMGs). Using single-molecule bioch...

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Detalles Bibliográficos
Autores principales: De Jesús-Kim, Lorraine, Friedman, Larry J, Lõoke, Marko, Ramsoomair, Christian K, Gelles, Jeff, Bell, Stephen P
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2021
Materias:
Cell Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7954526/
https://www.ncbi.nlm.nih.gov/pubmed/33616038
http://dx.doi.org/10.7554/eLife.65471

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7954526/
https://www.ncbi.nlm.nih.gov/pubmed/33616038
http://dx.doi.org/10.7554/eLife.65471

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