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P2X7 is a cytotoxic receptor….maybe not: implications for cancer
The tumor microenvironment is rich in extracellular ATP. This nucleotide affects both cancer and infiltrating immune cell responses by acting at P2 receptors, chiefly P2X7. ATP is then degraded to generate adenosine, a very powerful immunosuppressant. The purinergic hypothesis put forward by Geoff B...
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Springer Netherlands
2020
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7955003/ https://www.ncbi.nlm.nih.gov/pubmed/33011962 http://dx.doi.org/10.1007/s11302-020-09735-w |