P2X7 is a cytotoxic receptor….maybe not: implications for cancer

The tumor microenvironment is rich in extracellular ATP. This nucleotide affects both cancer and infiltrating immune cell responses by acting at P2 receptors, chiefly P2X7. ATP is then degraded to generate adenosine, a very powerful immunosuppressant. The purinergic hypothesis put forward by Geoff B...

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Detalles Bibliográficos
Autor principal: Di Virgilio, Francesco
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Netherlands 2020
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7955003/
https://www.ncbi.nlm.nih.gov/pubmed/33011962
http://dx.doi.org/10.1007/s11302-020-09735-w
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author Di Virgilio, Francesco
author_facet Di Virgilio, Francesco
author_sort Di Virgilio, Francesco
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description The tumor microenvironment is rich in extracellular ATP. This nucleotide affects both cancer and infiltrating immune cell responses by acting at P2 receptors, chiefly P2X7. ATP is then degraded to generate adenosine, a very powerful immunosuppressant. The purinergic hypothesis put forward by Geoff Burnstock prompted innovative investigation in this field and provided the intellectual framework to interpret a myriad of experimental findings. This is a short appraisal of how Geoff’s inspiration influenced cancer studies and my own investigation highlighting the key role of the P2X7 receptor.
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spelling pubmed-79550032021-03-28 P2X7 is a cytotoxic receptor….maybe not: implications for cancer Di Virgilio, Francesco Purinergic Signal Review Article The tumor microenvironment is rich in extracellular ATP. This nucleotide affects both cancer and infiltrating immune cell responses by acting at P2 receptors, chiefly P2X7. ATP is then degraded to generate adenosine, a very powerful immunosuppressant. The purinergic hypothesis put forward by Geoff Burnstock prompted innovative investigation in this field and provided the intellectual framework to interpret a myriad of experimental findings. This is a short appraisal of how Geoff’s inspiration influenced cancer studies and my own investigation highlighting the key role of the P2X7 receptor. Springer Netherlands 2020-10-04 2021-03 /pmc/articles/PMC7955003/ /pubmed/33011962 http://dx.doi.org/10.1007/s11302-020-09735-w Text en © The Author(s) 2020 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Review Article
Di Virgilio, Francesco
P2X7 is a cytotoxic receptor….maybe not: implications for cancer
title P2X7 is a cytotoxic receptor….maybe not: implications for cancer
title_full P2X7 is a cytotoxic receptor….maybe not: implications for cancer
title_fullStr P2X7 is a cytotoxic receptor….maybe not: implications for cancer
title_full_unstemmed P2X7 is a cytotoxic receptor….maybe not: implications for cancer
title_short P2X7 is a cytotoxic receptor….maybe not: implications for cancer
title_sort p2x7 is a cytotoxic receptor….maybe not: implications for cancer
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7955003/
https://www.ncbi.nlm.nih.gov/pubmed/33011962
http://dx.doi.org/10.1007/s11302-020-09735-w
work_keys_str_mv AT divirgiliofrancesco p2x7isacytotoxicreceptormaybenotimplicationsforcancer

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