Global discovery of lupus genetic risk variant allelic enhancer activity

Genome-wide association studies of Systemic Lupus Erythematosus (SLE) nominate 3073 genetic variants at 91 risk loci. To systematically screen these variants for allelic transcriptional enhancer activity, we construct a massively parallel reporter assay (MPRA) library comprising 12,396 DNA oligonucl...

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Detalles Bibliográficos
Autores principales: Lu, Xiaoming, Chen, Xiaoting, Forney, Carmy, Donmez, Omer, Miller, Daniel, Parameswaran, Sreeja, Hong, Ted, Huang, Yongbo, Pujato, Mario, Cazares, Tareian, Miraldi, Emily R., Ray, John P., de Boer, Carl G., Harley, John B., Weirauch, Matthew T., Kottyan, Leah C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7955039/
https://www.ncbi.nlm.nih.gov/pubmed/33712590
http://dx.doi.org/10.1038/s41467-021-21854-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7955039/
https://www.ncbi.nlm.nih.gov/pubmed/33712590
http://dx.doi.org/10.1038/s41467-021-21854-5

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