Direct catalytic asymmetric synthesis of α-chiral bicyclo[1.1.1]pentanes

Bicyclo[1.1.1]pentanes (BCPs) are important motifs in contemporary drug design as linear spacer units that improve pharmacokinetic profiles. The synthesis of BCPs featuring adjacent stereocenters is highly challenging, but desirable due to the fundamental importance of 3D chemical space in medicinal...

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Detalles Bibliográficos
Autores principales: Wong, Marie L. J., Sterling, Alistair J., Mousseau, James J., Duarte, Fernanda, Anderson, Edward A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7955048/
https://www.ncbi.nlm.nih.gov/pubmed/33712595
http://dx.doi.org/10.1038/s41467-021-21936-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7955048/
https://www.ncbi.nlm.nih.gov/pubmed/33712595
http://dx.doi.org/10.1038/s41467-021-21936-4

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