ADAR1 RNA editing enzyme regulates R-loop formation and genome stability at telomeres in cancer cells

ADAR1 is involved in adenosine-to-inosine RNA editing. The cytoplasmic ADAR1p150 edits 3’UTR double-stranded RNAs and thereby suppresses induction of interferons. Loss of this ADAR1p150 function underlies the embryonic lethality of Adar1 null mice, pathogenesis of the severe autoimmune disease Aicar...

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Detalles Bibliográficos
Autores principales: Shiromoto, Yusuke, Sakurai, Masayuki, Minakuchi, Moeko, Ariyoshi, Kentaro, Nishikura, Kazuko
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7955049/
https://www.ncbi.nlm.nih.gov/pubmed/33712600
http://dx.doi.org/10.1038/s41467-021-21921-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7955049/
https://www.ncbi.nlm.nih.gov/pubmed/33712600
http://dx.doi.org/10.1038/s41467-021-21921-x

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