Inhibitory mechanism of reveromycin A at the tRNA binding site of a class I synthetase

The polyketide natural product reveromycin A (RM-A) exhibits antifungal, anticancer, anti-bone metastasis, anti-periodontitis and anti-osteoporosis activities by selectively inhibiting eukaryotic cytoplasmic isoleucyl-tRNA synthetase (IleRS). Herein, a co-crystal structure suggests that the RM-A mol...

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Detalles Bibliográficos
Autores principales: Chen, Bingyi, Luo, Siting, Zhang, Songxuan, Ju, Yingchen, Gu, Qiong, Xu, Jun, Yang, Xiang-Lei, Zhou, Huihao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7955072/
https://www.ncbi.nlm.nih.gov/pubmed/33712620
http://dx.doi.org/10.1038/s41467-021-21902-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7955072/
https://www.ncbi.nlm.nih.gov/pubmed/33712620
http://dx.doi.org/10.1038/s41467-021-21902-0

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