Cargando…

Inhibitory mechanism of reveromycin A at the tRNA binding site of a class I synthetase

The polyketide natural product reveromycin A (RM-A) exhibits antifungal, anticancer, anti-bone metastasis, anti-periodontitis and anti-osteoporosis activities by selectively inhibiting eukaryotic cytoplasmic isoleucyl-tRNA synthetase (IleRS). Herein, a co-crystal structure suggests that the RM-A mol...

Descripción completa

Detalles Bibliográficos
Autores principales:	Chen, Bingyi, Luo, Siting, Zhang, Songxuan, Ju, Yingchen, Gu, Qiong, Xu, Jun, Yang, Xiang-Lei, Zhou, Huihao
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7955072/ https://www.ncbi.nlm.nih.gov/pubmed/33712620 http://dx.doi.org/10.1038/s41467-021-21902-0

Ejemplares similares

Author Correction: Inhibitory mechanism of reveromycin A at the tRNA binding site of a class I synthetase
por: Chen, Bingyi, et al.
Publicado: (2021)

The binding mode of orphan glycyl-tRNA synthetase with tRNA supports the synthetase classification and reveals large domain movements
por: Han, Lu, et al.
Publicado: (2023)

X-shaped structure of bacterial heterotetrameric tRNA synthetase suggests cryptic prokaryote functions and a rationale for synthetase classifications
por: Ju, Yingchen, et al.
Publicado: (2021)

Fragment screening and structural analyses highlight the ATP-assisted ligand binding for inhibitor discovery against type 1 methionyl-tRNA synthetase
por: Yi, Jia, et al.
Publicado: (2022)

ATP-Directed Capture of Bioactive Herbal-Based Medicine on Human tRNA Synthetase
por: Zhou, Huihao, et al.
Publicado: (2012)

Discovery of an Allosteric Binding Site in Kinetoplastid Methionyl-tRNA Synthetase
por: Torrie, Leah S., et al.
Publicado: (2020)

Negative catalysis by the editing domain of class I aminoacyl-tRNA synthetases
por: Zivkovic, Igor, et al.
Publicado: (2022)

Antibiotic hyper-resistance in a class I aminoacyl-tRNA synthetase with altered active site signature motif
por: Brkic, A., et al.
Publicado: (2023)

Backbone Brackets and Arginine Tweezers delineate Class I and Class II aminoacyl tRNA synthetases
por: Kaiser, Florian, et al.
Publicado: (2018)

CMT2D neuropathy is linked to the neomorphic binding activity of glycyl-tRNA synthetase
por: He, Weiwei, et al.
Publicado: (2015)

Relaxed Substrate Specificity Leads to Extensive tRNA Mischarging by Streptococcus pneumoniae Class I and Class II Aminoacyl-tRNA Synthetases
por: Shepherd, Jennifer, et al.
Publicado: (2014)

Histidyl-tRNA Synthetase Urzymes: CLASS I AND II AMINOACYL tRNA SYNTHETASE URZYMES HAVE COMPARABLE CATALYTIC ACTIVITIES FOR COGNATE AMINO ACID ACTIVATION
por: Li, Li, et al.
Publicado: (2011)

Evolution of acceptor stem tRNA recognition by class II prolyl-tRNA synthetase
por: An, Songon, et al.
Publicado: (2008)

Predicted class-I aminoacyl tRNA synthetase-like proteins in non-ribosomal peptide synthesis
por: Aravind, L, et al.
Publicado: (2010)

In silico detection of tRNA sequence features characteristic to aminoacyl-tRNA synthetase class membership
por: Jakó, Éena, et al.
Publicado: (2007)

β-carboline biomediators induce reveromycin production in Streptomyces sp. SN-593
por: Panthee, Suresh, et al.
Publicado: (2019)

Bacterial Aspartyl-tRNA Synthetase Has Glutamyl-tRNA Synthetase Activity
por: Rathnayake, Udumbara M., et al.
Publicado: (2019)

Aminoacyl-tRNA synthetases of the multi-tRNA synthetase complex and their role in tumorigenesis
por: Khan, Krishnendu, et al.
Publicado: (2022)

Determinants for tRNA-Dependent Pretransfer Editing in the Synthetic Site of Isoleucyl-tRNA Synthetase
por: Dulic, Morana, et al.
Publicado: (2014)

Localization and RNA Binding of Mitochondrial Aminoacyl tRNA Synthetases
por: Garin, Shahar, et al.
Publicado: (2020)

MD Simulations of tRNA and Aminoacyl-tRNA Synthetases: Dynamics, Folding, Binding, and Allostery
por: Li, Rongzhong, et al.
Publicado: (2015)

Aminoacyl-tRNA synthetases
por: Rubio Gomez, Miguel Angel, et al.
Publicado: (2020)

Expanding a tyrosyl-tRNA synthetase assay to other aminoacyl-tRNA synthetases
por: Richardson, Charles J., et al.
Publicado: (2015)

Aminoacyl-tRNA Synthetases: On Anti-Synthetase Syndrome and Beyond
por: Galindo-Feria, Angeles S., et al.
Publicado: (2022)

Identification of a binding site on soluble RANKL that can be targeted to inhibit soluble RANK-RANKL interactions and treat osteoporosis
por: Huang, Dane, et al.
Publicado: (2022)

Structural basis for the dynamics of human methionyl-tRNA synthetase in multi-tRNA synthetase complexes
por: Kim, Dong Kyu, et al.
Publicado: (2021)

Multidimensional Phylogenetic Metrics Identify Class I Aminoacyl-tRNA Synthetase Evolutionary Mosaicity and Inter-Modular Coupling
por: Carter, Charles W., et al.
Publicado: (2022)

Domain acquisition by class I aminoacyl-tRNA synthetase urzymes coordinated the catalytic functions of HVGH and KMSKS motifs
por: Tang, Guo Qing, et al.
Publicado: (2023)

Comparative modeling of class 1 lysyl tRNA synthetase from Treponema pallidum
por: Rao, Venkata Rao Dodaghatta Krishna, et al.
Publicado: (2006)

Chimeric design of pyrrolysyl-tRNA synthetase/tRNA pairs and canonical synthetase/tRNA pairs for genetic code expansion
por: Ding, Wenlong, et al.
Publicado: (2020)

Reveromycin A Administration Prevents Alveolar Bone Loss in Osteoprotegerin Knockout Mice with Periodontal Disease
por: Mizuno, Manami, et al.
Publicado: (2015)

The endless frontier of tRNA synthetases
por: Schimmel, Paul
Publicado: (2020)

Membrane binding of the insertion sequence of Proteus vulgaris L-amino acid deaminase stabilizes protein structure and increases catalytic activity
por: Ju, Yingchen, et al.
Publicado: (2017)

Coexistence of bacterial leucyl-tRNA synthetases with archaeal tRNA binding domains that distinguish tRNA(Leu) in the archaeal mode
por: Fang, Zhi-Peng, et al.
Publicado: (2014)

Anticodon-like binding of the HIV-1 tRNA-like element to human lysyl-tRNA synthetase
por: Liu, Sheng, et al.
Publicado: (2016)

Hierarchical groove discrimination by Class I and II aminoacyl-tRNA synthetases reveals a palimpsest of the operational RNA code in the tRNA acceptor-stem bases
por: Carter, Charles W, et al.
Publicado: (2018)

Sequential magnesium binding facilitates lysyl-tRNA synthetase to recognize ATP
por: Hei, Zhoufei, et al.
Publicado: (2023)

Statistical Evaluation of the Rodin–Ohno Hypothesis: Sense/Antisense Coding of Ancestral Class I and II Aminoacyl-tRNA Synthetases
por: Chandrasekaran, Srinivas Niranj, et al.
Publicado: (2013)

Crystal structure of human cytosolic aspartyl-tRNA synthetase, a component of multi-tRNA synthetase complex
por: Kim, Kyung Rok, et al.
Publicado: (2013)

Clone and functional analysis of Seryl-tRNA synthetase and Tyrosyl-tRNA synthetase from silkworm, Bombyx mori
por: Hu, Jingsheng, et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_k5mqtcpkcmd93bnr1gnnjc3crk