Cargando…

Maternal antibodies facilitate Amyloid-β clearance by activating Fc-receptor-Syk-mediated phagocytosis

Maternal antibodies (MAbs) protect against infections in immunologically-immature neonates. Maternally transferred immunity may also be harnessed to target diseases associated with endogenous protein misfolding and aggregation, such as Alzheimer’s disease (AD) and AD-pathology in Down syndrome (DS)....

Descripción completa

Detalles Bibliográficos
Autores principales:	Illouz, Tomer, Nicola, Raneen, Ben-Shushan, Linoy, Madar, Ravit, Biragyn, Arya, Okun, Eitan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7955073/ https://www.ncbi.nlm.nih.gov/pubmed/33712740 http://dx.doi.org/10.1038/s42003-021-01851-6

Ejemplares similares

Restoring microglial and astroglial homeostasis using DNA immunization in a Down Syndrome mouse model
por: Illouz, Tomer, et al.
Publicado: (2018)

L-Lactate Promotes Adult Hippocampal Neurogenesis
por: Lev-Vachnish, Yaeli, et al.
Publicado: (2019)

Sirt6 alters adult hippocampal neurogenesis
por: Okun, Eitan, et al.
Publicado: (2017)

A Critical Role for Syk in Signal Transduction and Phagocytosis Mediated by Fcγ Receptors on Macrophages
por: Crowley, Mary T., et al.
Publicado: (1997)

Therapeutic B-cell depletion reverses progression of Alzheimer’s disease
por: Kim, Ki, et al.
Publicado: (2021)

Syk facilitates phagosome-lysosome fusion by regulating actin-remodeling in complement-mediated phagocytosis
por: Tabata, Hiroyuki, et al.
Publicado: (2020)

Food and Age: It Takes Two to Degenerate
por: Nicola, Raneen, et al.
Publicado: (2020)

Syk-dependent tyrosine phosphorylation of 3BP2 is required for optimal FcRγ-mediated phagocytosis and chemokine expression in U937 cells
por: Chihara, Kazuyasu, et al.
Publicado: (2017)

Chronic Toxoplasma gondii infection enhances β-amyloid phagocytosis and clearance by recruited monocytes
por: Möhle, Luisa, et al.
Publicado: (2016)

Immune Dysregulation and the Increased Risk of Complications and Mortality Following Respiratory Tract Infections in Adults With Down Syndrome
por: Illouz, Tomer, et al.
Publicado: (2021)

Differential mast cell outcomes are sensitive to FcεRI-Syk binding kinetics
por: Schwartz, Samantha L., et al.
Publicado: (2017)

Docking of Syk to FcεRI is enhanced by Lyn but limited in duration by SHIP1
por: Kanagy, William K., et al.
Publicado: (2022)

Regulation of Syk activity by antiviral adaptor MAVS in FcεRI signaling pathway
por: Kawakami, Yuko, et al.
Publicado: (2023)

Effects of Microparticle Size and Fc Density on Macrophage Phagocytosis
por: Pacheco, Patricia, et al.
Publicado: (2013)

Complement receptor-3 negatively regulates the phagocytosis of degenerated myelin through tyrosine kinase Syk and cofilin
por: Hadas, Smadar, et al.
Publicado: (2012)

Comparison of the anti-allergic activity of Syk inhibitors with optimized Syk siRNAs in FcεRI-activated RBL-2H3 basophilic cells
por: Sanderson, Michael P., et al.
Publicado: (2010)

Combinatorial diversity of Syk recruitment driven by its multivalent engagement with FcεRIγ
por: Travers, Timothy, et al.
Publicado: (2019)

Pharmacological Stimulation of Phagocytosis Enhances Amyloid Plaque Clearance; Evidence from a Transgenic Mouse Model of ATTR Neuropathy
por: Fella, Eleni, et al.
Publicado: (2017)

Cannabidiol Enhances Microglial Beta-Amyloid Peptide Phagocytosis and Clearance via Vanilloid Family Type 2 Channel Activation
por: Yang, Shaobin, et al.
Publicado: (2022)

Internalization and degradation of macrophage Fc receptors during receptor-mediated phagocytosis
Publicado: (1983)

Tyrosine phosphorylation is required for Fc receptor-mediated phagocytosis in mouse macrophages
Publicado: (1993)

Syk promotes phagocytosis by inducing reactive oxygen species generation and suppressing SOCS1 in macrophage-mediated inflammatory responses
por: Yi, Young-Su, et al.
Publicado: (2022)

Intestinal Metabolites Influence Macrophage Phagocytosis and Clearance of Bacterial Infection
por: O’Callaghan, Amy A., et al.
Publicado: (2021)

Specific Susceptibility to COVID-19 in Adults with Down Syndrome
por: Illouz, Tomer, et al.
Publicado: (2021)

Correction to: Specific Susceptibility to COVID-19 in Adults with Down Syndrome
por: Illouz, Tomer, et al.
Publicado: (2021)

Correction to: Specific Susceptibility to COVID-19 in Adults with Down Syndrome
por: Illouz, Tomer, et al.
Publicado: (2021)

URMC-099 facilitates amyloid-β clearance in a murine model of Alzheimer’s disease
por: Kiyota, Tomomi, et al.
Publicado: (2018)

Reticulocalbin-1 Facilitates Microglial Phagocytosis
por: Ding, Ying, et al.
Publicado: (2015)

Rho is Required for the Initiation of Calcium Signaling and Phagocytosis by Fcγ Receptors in Macrophages
por: Hackam, David J., et al.
Publicado: (1997)

PHAGOCYTOSIS IN SUBACUTE BACTERIAL ENDOCARDITIS : LOCALIZATION OF THE PRIMARY OPSONIC SITE TO FC FRAGMENT
por: Quie, Paul G., et al.
Publicado: (1968)

Phagocytosis mediated by three distinct Fc gamma receptor classes on human leukocytes
Publicado: (1990)

Phospholipid Scramblase 1 Modulates FcR-Mediated Phagocytosis in Differentiated Macrophages
por: Herate, Cecile, et al.
Publicado: (2016)

2A4 binds soluble and insoluble light chain aggregates from AL amyloidosis patients and promotes clearance of amyloid deposits by phagocytosis (†)
por: Renz, Mark, et al.
Publicado: (2016)

Targeted Fcγ Receptor (FcγR)-mediated Clearance by a Biparatopic Bispecific Antibody
por: Kasturirangan, Srinath, et al.
Publicado: (2017)

Calcium transients during Fc receptor-mediated and nonspecific phagocytosis by murine peritoneal macrophages
Publicado: (1991)

Fc-receptor-mediated phagocytosis occurs in macrophages without an increase in average [Ca++]i
Publicado: (1986)

Colocalization of F-actin and talin during Fc receptor-mediated phagocytosis in mouse macrophages
Publicado: (1990)

Critical role for scaffolding adapter Gab2 in FcγR-mediated phagocytosis
por: Gu, Haihua, et al.
Publicado: (2003)

Use of a Monocyte Monolayer Assay to Evaluate Fcγ Receptor-mediated Phagocytosis
por: Tong, Tik Nga, et al.
Publicado: (2017)

Tight nanoscale clustering of Fcγ receptors using DNA origami promotes phagocytosis
por: Kern, Nadja, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_8i84023e3bk80id8l4iunih1or