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Interplay of BAF and MLL4 promotes cell type-specific enhancer activation

Cell type-specific enhancers are activated by coordinated actions of lineage-determining transcription factors (LDTFs) and chromatin regulators. The SWI/SNF chromatin remodeling complex BAF and the histone H3K4 methyltransferase MLL4 (KMT2D) are both implicated in enhancer activation. However, the i...

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Detalles Bibliográficos
Autores principales: Park, Young-Kwon, Lee, Ji-Eun, Yan, Zhijiang, McKernan, Kaitlin, O’Haren, Tommy, Wang, Weidong, Peng, Weiqun, Ge, Kai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7955098/
https://www.ncbi.nlm.nih.gov/pubmed/33712604
http://dx.doi.org/10.1038/s41467-021-21893-y