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Cryo-EM structure of amyloid fibrils formed by the entire low complexity domain of TDP-43
Amyotrophic lateral sclerosis and several other neurodegenerative diseases are associated with brain deposits of amyloid-like aggregates formed by the C-terminal fragments of TDP-43 that contain the low complexity domain of the protein. Here, we report the cryo-EM structure of amyloid formed from th...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2021
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7955110/ https://www.ncbi.nlm.nih.gov/pubmed/33712624 http://dx.doi.org/10.1038/s41467-021-21912-y |