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Cryo-EM structure of amyloid fibrils formed by the entire low complexity domain of TDP-43

Amyotrophic lateral sclerosis and several other neurodegenerative diseases are associated with brain deposits of amyloid-like aggregates formed by the C-terminal fragments of TDP-43 that contain the low complexity domain of the protein. Here, we report the cryo-EM structure of amyloid formed from th...

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Detalles Bibliográficos
Autores principales:	Li, Qiuye, Babinchak, W. Michael, Surewicz, Witold K.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7955110/ https://www.ncbi.nlm.nih.gov/pubmed/33712624 http://dx.doi.org/10.1038/s41467-021-21912-y

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