Cargando…

Discovery of fungal surface NADases predominantly present in pathogenic species

Nicotinamide adenine dinucleotide (NAD) is a key molecule in cellular bioenergetics and signalling. Various bacterial pathogens release NADase enzymes into the host cell that deplete the host’s NAD(+) pool, thereby causing rapid cell death. Here, we report the identification of NADases on the surfac...

Descripción completa

Detalles Bibliográficos
Autores principales:	Strømland, Øyvind, Kallio, Juha P., Pschibul, Annica, Skoge, Renate H., Harðardóttir, Hulda M., Sverkeli, Lars J., Heinekamp, Thorsten, Kniemeyer, Olaf, Migaud, Marie, Makarov, Mikhail V., Gossmann, Toni I., Brakhage, Axel A., Ziegler, Mathias
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7955114/ https://www.ncbi.nlm.nih.gov/pubmed/33712585 http://dx.doi.org/10.1038/s41467-021-21307-z

Ejemplares similares

Author Correction: Discovery of fungal surface NADases predominantly present in pathogenic species
por: Strømland, Øyvind, et al.
Publicado: (2021)

Novel Calcium-Binding Motif Stabilizes and Increases the Activity of Aspergillus fumigatus Ecto-NADase
por: Ferrario, Eugenio, et al.
Publicado: (2023)

Systems Biology of Fungal Infection
por: Horn, Fabian, et al.
Publicado: (2012)

Characterization of the Aspergillus fumigatus detoxification systems for reactive nitrogen intermediates and their impact on virulence
por: Lapp, Katrin, et al.
Publicado: (2014)

Distinct transcriptional responses to fludioxonil in Aspergillus fumigatus and its ΔtcsC and Δskn7 mutants reveal a crucial role for Skn7 in the cell wall reorganizations triggered by this antifungal
por: Schruefer, Sebastian, et al.
Publicado: (2023)

Interference of Aspergillus fumigatus with the immune response
por: Heinekamp, Thorsten, et al.
Publicado: (2014)

NADases as weapons for both plant pathogens and their hosts
por: Ogden, Sam C., et al.
Publicado: (2023)

Enzymatic and Chemical Syntheses of Vacor Analogs of Nicotinamide Riboside, NMN and NAD
por: Sverkeli, Lars Jansen, et al.
Publicado: (2021)

General Phenotype of NADase Induction by CLI Treatment in Streptococcus pyogenes
por: Tatsuno, Ichiro, et al.
Publicado: (2022)

A phylogenetic approach to explore the Aspergillus fumigatus conidial surface-associated proteome and its role in pathogenesis
por: Goldman, Gustavo, et al.
Publicado: (2023)

Human and Plant Fungal Pathogens: The Role of Secondary Metabolites
por: Scharf, Daniel H., et al.
Publicado: (2014)

Plant and prokaryotic TIR domains generate distinct cyclic ADPR NADase products
por: Bayless, Adam M., et al.
Publicado: (2023)

Structural insights into mechanisms of Argonaute protein-associated NADase activation in bacterial immunity
por: Wang, Xiaoshen, et al.
Publicado: (2023)

Conidial surface proteins at the interface of fungal infections
por: Blango, Matthew G., et al.
Publicado: (2019)

CD38‐NADase is a new major contributor to Duchenne muscular dystrophic phenotype
por: de Zélicourt, Antoine, et al.
Publicado: (2022)

Structural basis underlying the synergism of NADase and SLO during group A Streptococcus infection
por: Tsai, Wei-Jiun, et al.
Publicado: (2023)

NADase and now Ca(2+) channel, what else to learn about plant NLRs?
por: Wan, Li, et al.
Publicado: (2021)

Rhs NADase effectors and their immunity proteins are exchangeable mediators of inter-bacterial competition in Serratia
por: Hagan, Martin, et al.
Publicado: (2023)

Integrative analysis of the heat shock response in Aspergillus fumigatus
por: Albrecht, Daniela, et al.
Publicado: (2010)

Design, Synthesis and SAR Studies of NAD Analogues as Potent Inhibitors towards CD38 NADase
por: Wang, Shengjun, et al.
Publicado: (2014)

The SARM1 TIR NADase: Mechanistic Similarities to Bacterial Phage Defense and Toxin-Antitoxin Systems
por: DiAntonio, Aaron, et al.
Publicado: (2021)

Functional assessment of the cell-autonomous role of NADase CD38 in regulating CD8(+) T cell exhaustion
por: Ma, Kaili, et al.
Publicado: (2022)

Interplay between human STING genotype and bacterial NADase activity regulates inter-individual disease variability
por: Movert, Elin, et al.
Publicado: (2023)

Sequence divergence and diversity suggests ongoing functional diversification of vertebrate NAD metabolism
por: Gossmann, Toni I., et al.
Publicado: (2014)

Aspergillus fumigatus melanins: interference with the host endocytosis pathway and impact on virulence
por: Heinekamp, Thorsten, et al.
Publicado: (2013)

Detection of misfolded protein aggregates from a clinical perspective
por: Strømland, Øyvind, et al.
Publicado: (2016)

NADase as a target molecule of in vivo suppression of the toxicity in the invasive M-1 group A Streptococcal isolates
por: Tatsuno, Ichiro, et al.
Publicado: (2010)

Effects of chitin synthesis inhibitor treatment on Lepeophtheirus salmonis (Copepoda, Caligidae) larvae
por: Harðardóttir, Hulda María, et al.
Publicado: (2019)

Chitin Synthases Are Critical for Reproduction, Molting, and Digestion in the Salmon Louse (Lepeophtheirus salmonis)
por: Harðardóttir, Hulda María, et al.
Publicado: (2021)

Extrinsic extracellular DNA leads to biofilm formation and colocalizes with matrix polysaccharides in the human pathogenic fungus Aspergillus fumigatus
por: Shopova, Iordana, et al.
Publicado: (2013)

The complete genome sequence of CrRV-Ch01, a new member of the family Rhabdoviridae in the parasitic copepod Caligus rogercresseyi present on farmed Atlantic salmon (Salmo salar) in Chile
por: Økland, Arnfinn Lodden, et al.
Publicado: (2018)

The NADase-Negative Variant of the Streptococcus pyogenes Toxin NAD(+) Glycohydrolase Induces JNK1-Mediated Programmed Cellular Necrosis
por: Chandrasekaran, Sukantha, et al.
Publicado: (2016)

Products of gut microbial Toll/interleukin-1 receptor domain NADase activities in gnotobiotic mice and Bangladeshi children with malnutrition
por: Weagley, James S., et al.
Publicado: (2022)

Enrichment of SARM1 alleles encoding variants with constitutively hyperactive NADase in patients with ALS and other motor nerve disorders
por: Gilley, Jonathan, et al.
Publicado: (2021)

Early Evolutionary Selection of NAD Biosynthesis Pathway in Bacteria
por: Sharma, Suraj, et al.
Publicado: (2022)

Aspergillus fumigatus hijacks human p11 to redirect fungal-containing phagosomes to non-degradative pathway
por: Jia, Lei-Jie, et al.
Publicado: (2023)

CRISPR-Cas9-Based Discovery of the Verrucosidin Biosynthesis Gene Cluster in Penicillium polonicum
por: Valente, Silvia, et al.
Publicado: (2021)

Comparison of transcriptome technologies in the pathogenic fungus Aspergillus fumigatus reveals novel insights into the genome and MpkA dependent gene expression
por: Müller, Sebastian, et al.
Publicado: (2012)

HapX Mediates Iron Homeostasis in the Pathogenic Dermatophyte Arthroderma benhamiae but Is Dispensable for Virulence
por: Kröber, Antje, et al.
Publicado: (2016)

Pyomelanin Formation in Aspergillus fumigatus Requires HmgX and the Transcriptional Activator HmgR but Is Dispensable for Virulence
por: Keller, Sophia, et al.
Publicado: (2011)

Cannot write session to /tmp/vufind_sessions/sess_9j9grkg1nveabe5esqmk68ohv5