A deep learning method for HLA imputation and trans-ethnic MHC fine-mapping of type 1 diabetes

Conventional human leukocyte antigen (HLA) imputation methods drop their performance for infrequent alleles, which is one of the factors that reduce the reliability of trans-ethnic major histocompatibility complex (MHC) fine-mapping due to inter-ethnic heterogeneity in allele frequency spectra. We d...

Descripción completa

Detalles Bibliográficos
Autores principales: Naito, Tatsuhiko, Suzuki, Ken, Hirata, Jun, Kamatani, Yoichiro, Matsuda, Koichi, Toda, Tatsushi, Okada, Yukinori
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7955122/
https://www.ncbi.nlm.nih.gov/pubmed/33712626
http://dx.doi.org/10.1038/s41467-021-21975-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7955122/
https://www.ncbi.nlm.nih.gov/pubmed/33712626
http://dx.doi.org/10.1038/s41467-021-21975-x

Ejemplares similares