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A deep learning method for HLA imputation and trans-ethnic MHC fine-mapping of type 1 diabetes

Conventional human leukocyte antigen (HLA) imputation methods drop their performance for infrequent alleles, which is one of the factors that reduce the reliability of trans-ethnic major histocompatibility complex (MHC) fine-mapping due to inter-ethnic heterogeneity in allele frequency spectra. We d...

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Detalles Bibliográficos
Autores principales:	Naito, Tatsuhiko, Suzuki, Ken, Hirata, Jun, Kamatani, Yoichiro, Matsuda, Koichi, Toda, Tatsushi, Okada, Yukinori
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7955122/ https://www.ncbi.nlm.nih.gov/pubmed/33712626 http://dx.doi.org/10.1038/s41467-021-21975-x

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