Pervasive cooperative mutational effects on multiple catalytic enzyme traits emerge via long-range conformational dynamics

Multidimensional fitness landscapes provide insights into the molecular basis of laboratory and natural evolution. To date, such efforts usually focus on limited protein families and a single enzyme trait, with little concern about the relationship between protein epistasis and conformational dynami...

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Detalles Bibliográficos
Autores principales: Acevedo-Rocha, Carlos G., Li, Aitao, D’Amore, Lorenzo, Hoebenreich, Sabrina, Sanchis, Joaquin, Lubrano, Paul, Ferla, Matteo P., Garcia-Borràs, Marc, Osuna, Sílvia, Reetz, Manfred T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7955134/
https://www.ncbi.nlm.nih.gov/pubmed/33712579
http://dx.doi.org/10.1038/s41467-021-21833-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7955134/
https://www.ncbi.nlm.nih.gov/pubmed/33712579
http://dx.doi.org/10.1038/s41467-021-21833-w

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