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Pervasive cooperative mutational effects on multiple catalytic enzyme traits emerge via long-range conformational dynamics
Multidimensional fitness landscapes provide insights into the molecular basis of laboratory and natural evolution. To date, such efforts usually focus on limited protein families and a single enzyme trait, with little concern about the relationship between protein epistasis and conformational dynami...
| Autores principales: | , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2021
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7955134/ https://www.ncbi.nlm.nih.gov/pubmed/33712579 http://dx.doi.org/10.1038/s41467-021-21833-w |