Structural Basis of CYRI-B Direct Competition with Scar/WAVE Complex for Rac1

Rac1 is a major regulator of actin dynamics, with GTP-bound Rac1 promoting actin assembly via the Scar/WAVE complex. CYRI competes with Scar/WAVE for interaction with Rac1 in a feedback loop regulating actin dynamics. Here, we reveal the nature of the CYRI-Rac1 interaction, through crystal structure...

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Detalles Bibliográficos
Autores principales: Yelland, Tamas, Le, Anh Hoang, Nikolaou, Savvas, Insall, Robert, Machesky, Laura, Ismail, Shehab
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7955166/
https://www.ncbi.nlm.nih.gov/pubmed/33217330
http://dx.doi.org/10.1016/j.str.2020.11.003

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7955166/
https://www.ncbi.nlm.nih.gov/pubmed/33217330
http://dx.doi.org/10.1016/j.str.2020.11.003

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