Dimeric Structure of the Pseudokinase IRAK3 Suggests an Allosteric Mechanism for Negative Regulation

Interleukin-1 receptor associated kinases (IRAKs) are key players in innate immune signaling that mediate the host response to pathogens. In contrast to the active kinases IRAK1 and IRAK4, IRAK2 and IRAK3 are pseudokinases lacking catalytic activity and their functions are poorly understood. IRAK3 i...

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Detalles Bibliográficos
Autores principales: Lange, Sven M., Nelen, Marina I., Cohen, Philip, Kulathu, Yogesh
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7955167/
https://www.ncbi.nlm.nih.gov/pubmed/33238146
http://dx.doi.org/10.1016/j.str.2020.11.004

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7955167/
https://www.ncbi.nlm.nih.gov/pubmed/33238146
http://dx.doi.org/10.1016/j.str.2020.11.004

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