CRTC1/MAML2 directs a PGC-1α-IGF-1 circuit that confers vulnerability to PPARγ inhibition

Mucoepidermoid carcinoma (MEC) is a life-threatening salivary gland cancer that is driven primarily by a transcriptional coactivator fusion composed of cyclic AMP-regulated transcriptional coactivator 1 (CRTC1) and mastermind-like 2 (MAML2). The mechanisms by which the chimeric CRTC1/MAML2 (C1/M2) o...

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Detalles Bibliográficos
Autores principales: Musicant, Adele M., Parag-Sharma, Kshitij, Gong, Weida, Sengupta, Monideepa, Chatterjee, Arindam, Henry, Erin C., Tsai, Yi-Hsuan, Hayward, Michele C., Sheth, Siddharth, Betancourt, Renee, Hackman, Trevor G., Padilla, Ricardo J., Parker, Joel S., Giudice, Jimena, Flaveny, Colin A., Hayes, David N., Amelio, Antonio L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7955229/
https://www.ncbi.nlm.nih.gov/pubmed/33626346
http://dx.doi.org/10.1016/j.celrep.2021.108768

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7955229/
https://www.ncbi.nlm.nih.gov/pubmed/33626346
http://dx.doi.org/10.1016/j.celrep.2021.108768

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