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MK2‐Deficient Mice Are Bradycardic and Display Delayed Hypertrophic Remodeling in Response to a Chronic Increase in Afterload
BACKGROUND: Mitogen‐activated protein kinase–activated protein kinase‐2 (MK2) is a protein serine/threonine kinase activated by p38α/β. Herein, we examine the cardiac phenotype of pan MK2‐null (MK2(−/−)) mice. METHODS AND RESULTS: Survival curves for male MK2(+/+) and MK2(−/−) mice did not differ (M...
Autores principales: | , , , , , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7955338/ https://www.ncbi.nlm.nih.gov/pubmed/33533257 http://dx.doi.org/10.1161/JAHA.120.017791 |