MK2‐Deficient Mice Are Bradycardic and Display Delayed Hypertrophic Remodeling in Response to a Chronic Increase in Afterload

BACKGROUND: Mitogen‐activated protein kinase–activated protein kinase‐2 (MK2) is a protein serine/threonine kinase activated by p38α/β. Herein, we examine the cardiac phenotype of pan MK2‐null (MK2(−/−)) mice. METHODS AND RESULTS: Survival curves for male MK2(+/+) and MK2(−/−) mice did not differ (M...

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Detalles Bibliográficos
Autores principales: Ruiz, Matthieu, Khairallah, Maya, Dingar, Dharmendra, Vaniotis, George, Khairallah, Ramzi J., Lauzier, Benjamin, Thibault, Simon, Trépanier, Joëlle, Shi, Yanfen, Douillette, Annie, Hussein, Bahira, Nawaito, Sherin Ali, Sahadevan, Pramod, Nguyen, Albert, Sahmi, Fatiha, Gillis, Marc‐Antoine, Sirois, Martin G., Gaestel, Matthias, Stanley, William C., Fiset, Céline, Tardif, Jean‐Claude, Allen, Bruce G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7955338/
https://www.ncbi.nlm.nih.gov/pubmed/33533257
http://dx.doi.org/10.1161/JAHA.120.017791

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