ZINC40099027 activates human focal adhesion kinase by accelerating the enzymatic activity of the FAK kinase domain

Focal adhesion kinase (FAK) regulates gastrointestinal epithelial restitution and healing. ZINC40099027 (Zn27) activates cellular FAK and promotes intestinal epithelial wound closure in vitro and in mice. However, whether Zn27 activates FAK directly or indirectly remains unknown. We evaluated Zn27 p...

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Detalles Bibliográficos
Autores principales: Rashmi, More, Shyam K., Wang, Qinggang, Vomhof‐DeKrey, Emilie E., Porter, James E., Basson, Marc D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7955952/
https://www.ncbi.nlm.nih.gov/pubmed/33715263
http://dx.doi.org/10.1002/prp2.737

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7955952/
https://www.ncbi.nlm.nih.gov/pubmed/33715263
http://dx.doi.org/10.1002/prp2.737

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