The multi-kinase inhibitor TG02 induces apoptosis and blocks B-cell receptor signaling in chronic lymphocytic leukemia through dual mechanisms of action

The constitutive activation of B-cell receptor (BCR) signaling, together with the overexpression of the Bcl-2 family anti-apoptotic proteins, represents two hallmarks of chronic lymphocytic leukemia (CLL) that drive leukemia cell proliferation and sustain their survival. TG02 is a small molecule mul...

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Detalles Bibliográficos
Autores principales: Chen, Rong, Tsai, Jennifer, Thompson, Philip A., Chen, Yuling, Xiong, Ping, Liu, Chaomei, Burrows, Francis, Sivina, Mariela, Burger, Jan A., Keating, Michael J., Wierda, William G., Plunkett, William
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7956145/
https://www.ncbi.nlm.nih.gov/pubmed/33714981
http://dx.doi.org/10.1038/s41408-021-00436-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7956145/
https://www.ncbi.nlm.nih.gov/pubmed/33714981
http://dx.doi.org/10.1038/s41408-021-00436-0

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