One-Step Generation of Multiple Gene-Edited Pigs by Electroporation of the CRISPR/Cas9 System into Zygotes to Reduce Xenoantigen Biosynthesis

Xenoantigens cause hyperacute rejection and limit the success of interspecific xenografts. Therefore, genes involved in xenoantigen biosynthesis, such as GGTA1, CMAH, and B4GALNT2, are key targets to improve the outcomes of xenotransplantation. In this study, we introduced a CRISPR/Cas9 system simul...

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Detalles Bibliográficos
Autores principales: Tanihara, Fuminori, Hirata, Maki, Nguyen, Nhien Thi, Sawamoto, Osamu, Kikuchi, Takeshi, Otoi, Takeshige
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7956194/
https://www.ncbi.nlm.nih.gov/pubmed/33668187
http://dx.doi.org/10.3390/ijms22052249

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7956194/
https://www.ncbi.nlm.nih.gov/pubmed/33668187
http://dx.doi.org/10.3390/ijms22052249

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