Pharmacological Activation of p53 during Human Monocyte to Macrophage Differentiation Attenuates Their Pro-Inflammatory Activation by TLR4, TLR7 and TLR8 Agonists

SIMPLE SUMMARY: Pharmacological activation of tumor suppressor p53 is a promising therapeutic strategy for a range of hematologic and solid cancers. Whether p53 activation augments or suppresses anti-tumor innate immunity is less understood. Here we show that treatment of differentiating human macro...

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Detalles Bibliográficos
Autores principales: Namgaladze, Dmitry, Brüne, Bernhard
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7956237/
https://www.ncbi.nlm.nih.gov/pubmed/33668835
http://dx.doi.org/10.3390/cancers13050958

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7956237/
https://www.ncbi.nlm.nih.gov/pubmed/33668835
http://dx.doi.org/10.3390/cancers13050958

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