Blocking Aerobic Glycolysis by Targeting Pyruvate Dehydrogenase Kinase in Combination with EGFR TKI and Ionizing Radiation Increases Therapeutic Effect in Non-Small Cell Lung Cancer Cells

SIMPLE SUMMARY: Non-small cell lung cancer (NSCLC) patients harboring oncogenic mutations in the epidermal growth factor receptor (EGFR) inevitably develop resistance to targeted EGFR tyrosine kinase inhibitors (TKI) therapy. To support malignant features associated with cancer development and thera...

Descripción completa

Detalles Bibliográficos
Autores principales: Dyrstad, Sissel E., Lotsberg, Maria L., Tan, Tuan Zea, Pettersen, Ina K. N., Hjellbrekke, Silje, Tusubira, Deusdedit, Engelsen, Agnete S. T., Daubon, Thomas, Mourier, Arnaud, Thiery, Jean Paul, Dahl, Olav, Lorens, James B., Tronstad, Karl Johan, Røsland, Gro V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7956357/
https://www.ncbi.nlm.nih.gov/pubmed/33668151
http://dx.doi.org/10.3390/cancers13050941

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7956357/
https://www.ncbi.nlm.nih.gov/pubmed/33668151
http://dx.doi.org/10.3390/cancers13050941

Ejemplares similares