Inhibition of PI3K Isoform p110γ Increases Both Anti-Tumor and Immunosuppressive Responses to Aggressive Murine Head and Neck Squamous Cell Carcinoma with Low Immunogenicity

SIMPLE SUMMARY: Poorly immunogenic head and neck squamous carcinomas (HNSCC) remain difficult to treat due to poor response rates to immunotherapy. Inhibition of the PI3K catalytic subunit p110γ, which is expressed in leukocytes and some HNSCCs, has shown promise in treating HNSCC; with clinical tri...

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Detalles Bibliográficos
Autores principales: Anderson, Kelvin, Ryan, Nathan, Alkhimovitch, Anastasia, Siddiqui, Arham, Oghumu, Steve
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7956466/
https://www.ncbi.nlm.nih.gov/pubmed/33668795
http://dx.doi.org/10.3390/cancers13050953

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7956466/
https://www.ncbi.nlm.nih.gov/pubmed/33668795
http://dx.doi.org/10.3390/cancers13050953

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