Cargando…

Inhibition of PI3K Isoform p110γ Increases Both Anti-Tumor and Immunosuppressive Responses to Aggressive Murine Head and Neck Squamous Cell Carcinoma with Low Immunogenicity

SIMPLE SUMMARY: Poorly immunogenic head and neck squamous carcinomas (HNSCC) remain difficult to treat due to poor response rates to immunotherapy. Inhibition of the PI3K catalytic subunit p110γ, which is expressed in leukocytes and some HNSCCs, has shown promise in treating HNSCC; with clinical tri...

Descripción completa

Detalles Bibliográficos
Autores principales:	Anderson, Kelvin, Ryan, Nathan, Alkhimovitch, Anastasia, Siddiqui, Arham, Oghumu, Steve
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7956466/ https://www.ncbi.nlm.nih.gov/pubmed/33668795 http://dx.doi.org/10.3390/cancers13050953

Ejemplares similares

STAT1 is regulated by TRIM24 and promotes immunosuppression in head and neck squamous carcinoma cells, but enhances T cell antitumour immunity in the tumour microenvironment
por: Anderson, Kelvin, et al.
Publicado: (2022)

PI3K-γ inhibitors in the therapeutic intervention of diseases caused by obligate intracellular pathogens
por: Oghumu, Steve, et al.
Publicado: (2013)

Black Raspberries and Protocatechuic Acid Mitigate DNFB-Induced Contact Hypersensitivity by Down-Regulating Dendritic Cell Activation and Inhibiting Mediators of Effector Responses
por: Anderson, Kelvin, et al.
Publicado: (2020)

Black raspberry extract inhibits regulatory T-cell activity in a murine model of head and neck squamous cell carcinoma chemoprevention
por: Ryan, Nathan M., et al.
Publicado: (2022)

Both p110α and p110β isoforms of PI3K can modulate the impact of loss-of-function of the PTEN tumour suppressor
por: Berenjeno, Inma M., et al.
Publicado: (2012)

Deficiency of PI3-Kinase catalytic isoforms p110γ and p110δ in mice enhances the IL-17/G-CSF axis and induces neutrophilia
por: Bucher, Kirsten, et al.
Publicado: (2017)

PI3K p110γ Deletion Attenuates Murine Atherosclerosis by Reducing Macrophage Proliferation but Not Polarization or Apoptosis in Lesions
por: Zotes, Teresa M., et al.
Publicado: (2013)

Critical roles for the phosphatidylinositide 3-kinase isoforms p110β and p110γ in thrombopoietin-mediated priming of platelet function
por: Moore, Samantha F., et al.
Publicado: (2019)

Inhibition of the p110α isoform of PI 3-kinase stimulates nonfunctional tumor angiogenesis
por: Soler, Adriana, et al.
Publicado: (2013)

Antigen receptor signalling: a distinctive role for the p110δ isoform of PI3K
por: Okkenhaug, Klaus, et al.
Publicado: (2007)

The Δ133p53β isoform promotes an immunosuppressive environment leading to aggressive prostate cancer
por: Kazantseva, Marina, et al.
Publicado: (2019)

Dominant Role of the p110β Isoform of PI3K over p110α in Energy Homeostasis Regulation by POMC and AgRP Neurons
por: Al-Qassab, Hind, et al.
Publicado: (2009)

Oncogenic Mutations of p110α Isoform of PI 3-Kinase Upregulate Its Protein Kinase Activity
por: Buchanan, Christina M., et al.
Publicado: (2013)

Functional impact and molecular binding modes of drugs that target the PI3K isoform p110δ
por: Hassenrück, Floyd, et al.
Publicado: (2023)

Allosteric activation or inhibition of PI3Kγ mediated through conformational changes in the p110γ helical domain
por: Harris, Noah J, et al.
Publicado: (2023)

Allosteric activation or inhibition of PI3Kγ mediated through conformational changes in the p110γ helical domain
por: Harris, Noah J, et al.
Publicado: (2023)

An SS18::NEDD4 cutaneous spindled and epithelioid sarcoma: An hitherto unclassified cutaneous sarcoma, resembling epithelioid sarcoma with aggressive clinical behavior
por: Patton, Ashley, et al.
Publicado: (2022)

PTEN regulated PI3K-p110 and AKT isoform plasticity controls metastatic prostate cancer progression
por: Miller, Karina, et al.
Publicado: (2023)

The PI3K p110α isoform regulates endothelial adherens junctions via Pyk2 and Rac1
por: Cain, Robert J., et al.
Publicado: (2010)

Inhibition of PI3 kinase isoform p110α suppresses neuroblastoma growth and induces the reduction of Anaplastic Lymphoma Kinase
por: Guo, Yue, et al.
Publicado: (2022)

$\pi$p->$\pi$ $\pi$ N reactions near threshold-80-110
por: CERN. Geneva. Proton Synchrotron and Synchrocyclotron Committee
Publicado: (1980)

Inhibition of PI3K Prevents the Proliferation and Differentiation of Human Lung Fibroblasts into Myofibroblasts: The Role of Class I P110 Isoforms
por: Conte, Enrico, et al.
Publicado: (2011)

Immunogenic-cell-killing and immunosuppression-inhibiting nanomedicine
por: Wang, Ying, et al.
Publicado: (2020)

PI3K p110β isoform synergizes with JNK in the regulation of glioblastoma cell proliferation and migration through Akt and FAK inhibition
por: Zhao, Hua-Fu, et al.
Publicado: (2016)

Effect of combined inhibition of p110 alpha PI3K isoform and STAT3 pathway in ovarian cancer platinum-based resistance
por: Le Naour, Augustin, et al.
Publicado: (2018)

IGF‐1 regulates astrocytic phagocytosis and inflammation through the p110α isoform of PI3K in a sex‐specific manner
por: Pinto‐Benito, Daniel, et al.
Publicado: (2022)

Quassinoid analogs with enhanced efficacy for treatment of hematologic malignancies target the PI3Kγ isoform
por: Pei, Yonggang, et al.
Publicado: (2020)

Run no. 110 - Physics Run (26 FA both rings)
por: Jones, E
Publicado: (1971)

Run no. 110 - Physics Run (26 FA both rings)
por: Jones, E
Publicado: (1971)

Quantitation of class IA PI3Ks in mice reveals p110-free-p85s and isoform-selective subunit associations and recruitment to receptors
por: Tsolakos, N., et al.
Publicado: (2018)

Immunosuppressive IBD drugs and COVID-19 vaccine immunogenicity
por: Hindson, Jordan
Publicado: (2022)

Aggressive tumors in a patient with HIV-induced immunosuppression
por: Campos, Luana Moraes, et al.
Publicado: (2021)

Immunosuppressive glycoproteins associate with breast tumor fibrosis and aggression
por: Metcalf, Kevin James, et al.
Publicado: (2022)

PI3Kδ and PI3Kγ isoforms have distinct functions in regulating pro-tumoural signalling in the multiple myeloma microenvironment
por: Piddock, R E, et al.
Publicado: (2017)

Structure of the phosphoinositide 3-kinase (PI3K) p110γ-p101 complex reveals molecular mechanism of GPCR activation
por: Rathinaswamy, Manoj K., et al.
Publicado: (2021)

Immunosuppressive plasma cells impede T cell-dependent immunogenic chemotherapy
por: Shalapour, Shabnam, et al.
Publicado: (2015)

Isoform-selective induction of human p110δ PI3K expression by TNFα: identification of a new and inducible PIK3CD promoter
por: Whitehead, Maria A., et al.
Publicado: (2012)

The p110α and p110β Isoforms of Class I Phosphatidylinositol 3-Kinase Are Involved in Toll-Like Receptor 5 Signaling in Epithelial Cells
por: Ivison, Sabine M., et al.
Publicado: (2010)

Class I Phosphoinositide 3-Kinase PIK3CA/p110α and PIK3CB/p110β Isoforms in Endometrial Cancer
por: Mazloumi Gavgani, Fatemeh, et al.
Publicado: (2018)

The Novel CXCL12γ Isoform Encodes an Unstructured Cationic Domain Which Regulates Bioactivity and Interaction with Both Glycosaminoglycans and CXCR4
por: Laguri, Cédric, et al.
Publicado: (2007)

Cannot write session to /tmp/vufind_sessions/sess_1mio3qvt856pf543r41hbiajpl