Cargando…

Anti-Tumor Effects of a Penetratin Peptide Targeting Transcription of E2F-1, 2 and 3a Is Enhanced When Used in Combination with Pemetrexed or Cisplatin

SIMPLE SUMMARY: The E2F family of transcription factors are essential for cell proliferation, differentiation, and DNA repair. They are commonly overexpressed or dysregulated in cancer as a consequence of inactivation or mutations in the retinoblastoma protein. Therefore, one or more of the activati...

Descripción completa

Detalles Bibliográficos
Autores principales:	Rather, Gulam Mohmad, Anyanwu, Michael, Minko, Tamara, Garbuzenko, Olga, Szekely, Zoltan, Bertino, Joseph R.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7956530/ https://www.ncbi.nlm.nih.gov/pubmed/33652640 http://dx.doi.org/10.3390/cancers13050972

Ejemplares similares

Modeling and antitumor studies of a modified L–penetratin peptide targeting E2F in lung cancer and prostate cancer
por: Shaik, Tazeem, et al.
Publicado: (2018)

A novel peptide that inhibits E2F transcription and regresses prostate tumor xenografts
por: Xie, Xiaoqi, et al.
Publicado: (2014)

A Novel Antibody-Toxin Conjugate to Treat Mantle Cell Lymphoma
por: Rather, Gulam M., et al.
Publicado: (2019)

The Homeodomain Derived Peptide Penetratin Induces Curvature of Fluid Membrane Domains
por: Lamazière, Antonin, et al.
Publicado: (2008)

Non-viral systemic delivery of siRNA or antisense oligonucleotides targeted to Jun N-terminal kinase 1 prevents cellular hypoxic damage
por: Betigeri, Seema, et al.
Publicado: (2010)

Efficient splicing correction by PNA conjugation to an R(6)-Penetratin delivery peptide
por: Abes, Saïd, et al.
Publicado: (2007)

Efficient splicing correction by PNA conjugation to an R6-Penetratin delivery peptide
por: Abes, Saïd, et al.
Publicado: (2007)

Inhalation treatment of lung cancer: the influence of composition, size and shape of nanocarriers on their lung accumulation and retention
por: Garbuzenko, Olga B., et al.
Publicado: (2014)

Distinct Behaviour of the Homeodomain Derived Cell Penetrating Peptide Penetratin in Interaction with Different Phospholipids
por: Maniti, Ofelia, et al.
Publicado: (2010)

Antibacterial Properties of Small-Size Peptide Derived from Penetratin against Oral Streptococci
por: Li, Meng, et al.
Publicado: (2021)

Shortened Penetratin Cell-Penetrating Peptide Is Insufficient for Cytosolic Delivery of a Grb7 Targeting Peptide
por: Watson, Gabrielle M., et al.
Publicado: (2017)

Biodegradable Janus Nanoparticles for Local Pulmonary Delivery of Hydrophilic and Hydrophobic Molecules to the Lungs
por: Garbuzenko, Olga B., et al.
Publicado: (2014)

Metastatic and triple-negative breast cancer: challenges and treatment options
por: Al-Mahmood, Sumayah, et al.
Publicado: (2018)

Comparative Immunogenicity of a Cytotoxic T Cell Epitope Delivered by Penetratin and TAT Cell Penetrating Peptides
por: Brooks, Nicole, et al.
Publicado: (2015)

Investigation of the Transport Pathways Associated with Enhanced Brain Delivery of Peptide Drugs by Intranasal Coadministration with Penetratin
por: Kamei, Noriyasu, et al.
Publicado: (2021)

A penetratin-derived peptide reduces the membrane permeabilization and cell toxicity of α-synuclein oligomers
por: Pirhaghi, Mitra, et al.
Publicado: (2022)

Hyperhydration with cisplatin does not influence pemetrexed exposure
por: de Rouw, Nikki, et al.
Publicado: (2021)

Tumor-Targeted Responsive Nanoparticle-Based Systems for Magnetic Resonance Imaging and Therapy
por: Savla, Ronak, et al.
Publicado: (2014)

Strategy to enhance lung cancer treatment by five essential elements: inhalation delivery, nanotechnology, tumor-receptor targeting, chemo- and gene therapy
por: Garbuzenko, Olga B., et al.
Publicado: (2019)

Systematic Screening of Penetratin’s Protein Targets by Yeast Proteome Microarrays
por: Shah, Pramod, et al.
Publicado: (2022)

Stereoisomer-Dependent Membrane Association and Capacity for Insulin Delivery Facilitated by Penetratin
por: Birch, Ditlev, et al.
Publicado: (2023)

Pemetrexed-cisplatin with concurrent thoracic radiation after pemetrexed-cisplatin induction in patients with unresectable locally advanced non-squamous NSCLC: results by age subgroup
por: Garrido, Pilar, et al.
Publicado: (2017)

Activation of Alpha Chymotrypsin by Three Phase Partitioning Is Accompanied by Aggregation
por: Rather, Gulam Mohmad, et al.
Publicado: (2012)

Review of pemetrexed in combination with cisplatin for the treatment of malignant pleural mesothelioma
por: Goudar, Ranjit K
Publicado: (2008)

Impact Of Penetratin Stereochemistry On The Oral Bioavailability Of Insulin-Loaded Solid Lipid Nanoparticles
por: Alsulays, Bader B, et al.
Publicado: (2019)

Relationships between Membrane Binding, Affinity and Cell Internalization Efficacy of a Cell-Penetrating Peptide: Penetratin as a Case Study
por: Alves, Isabel D., et al.
Publicado: (2011)

Activated matriptase as a target to treat breast cancer with a drug conjugate
por: Rather, Gulam M., et al.
Publicado: (2018)

Protective Effect of Penetratin Analogue-Tagged SOD1 on Cisplatin-Induced Nephrotoxicity through Inhibiting Oxidative Stress and JNK/p38 MAPK Signaling Pathway
por: Wang, Xiao-lu, et al.
Publicado: (2021)

Elucidating the Function of Penetratin and a Static Magnetic Field in Cellular Uptake of Magnetic Nanoparticles
por: Chaudhary, Suman, et al.
Publicado: (2013)

α‐synuclein conformational antibodies fused to penetratin are effective in models of Lewy body disease
por: Spencer, Brian, et al.
Publicado: (2016)

Intraocular siRNA Delivery Mediated by Penetratin Derivative to Silence Orthotopic Retinoblastoma Gene
por: Gao, Xin, et al.
Publicado: (2023)

Therapeutic effects of sequential chemoradiotherapy with pemetrexed and cisplatin on locally advanced laryngeal cancer
por: Tao, Youmao, et al.
Publicado: (2016)

A Case Report of Primary Pericardial Malignant Mesothelioma Treated with Pemetrexed and Cisplatin
por: Kim, Jung Sun, et al.
Publicado: (2017)

An ω-3, but Not an ω-6 Polyunsaturated Fatty Acid Decreases Membrane Dipole Potential and Stimulates Endo-Lysosomal Escape of Penetratin
por: Zakany, Florina, et al.
Publicado: (2021)

Synthesis and Ex Vivo Trans-Corneal Permeation of Penetratin Analogues as Ophthalmic Carriers: Preliminary Results
por: Pescina, Silvia, et al.
Publicado: (2020)

Far-UV circular dichroism signatures indicate fluorophore labeling induced conformational changes of penetratin
por: Zsila, Ferenc
Publicado: (2022)

High-Throughput Virtual Screening, Molecular Dynamics Simulation, and Enzyme Kinetics Identified ZINC84525623 as a Potential Inhibitor of NDM-1
por: Rehman, Md Tabish, et al.
Publicado: (2019)

PNC-27, a Chimeric p53-Penetratin Peptide Binds to HDM-2 in a p53 Peptide-like Structure, Induces Selective Membrane-Pore Formation and Leads to Cancer Cell Lysis
por: Sarafraz-Yazdi, Ehsan, et al.
Publicado: (2022)

Prognostic value of serum leptin in advanced lung adenocarcinoma patients with cisplatin/pemetrexed chemotherapy
por: MOU, WENJUN, et al.
Publicado: (2014)

Optimal Scheduling of Bevacizumab and Pemetrexed/Cisplatin Dosing in Non‐Small Cell Lung Cancer
por: Schneider, Benjamin K., et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_js6k9u8obo2igrdr3dc1mv3bpg