New 3-Aryl-2-(2-thienyl)acrylonitriles with High Activity Against Hepatoma Cells

New 2-(thien-2-yl)-acrylonitriles with putative kinase inhibitory activity were prepared and tested for their antineoplastic efficacy in hepatoma models. Four out of the 14 derivatives were shown to inhibit hepatoma cell proliferation at (sub-)micromolar concentrations with IC(50) values below that...

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Detalles Bibliográficos
Autores principales: Schaller, Eva, Ma, Andi, Gosch, Lisa Chiara, Klefenz, Adrian, Schaller, David, Goehringer, Nils, Kaps, Leonard, Schuppan, Detlef, Volkamer, Andrea, Schobert, Rainer, Biersack, Bernhard, Nitzsche, Bianca, Höpfner, Michael
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7956560/
https://www.ncbi.nlm.nih.gov/pubmed/33668139
http://dx.doi.org/10.3390/ijms22052243

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7956560/
https://www.ncbi.nlm.nih.gov/pubmed/33668139
http://dx.doi.org/10.3390/ijms22052243

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